![]() Fine grained osseointegrative coating improves biocompatibility of PEEK in heterotopic sheep model. Spine interbody implants: material selection and modification, functionalization and bioactivation of surfaces to improve osseointegration. Rao PJ, Pelletier MH, Walsh WR, Mobbs RJ. ![]() Plasma- sprayed titanium coating to polyetheretherketone improves the bone- implant interface. ![]() ![]() Walsh WR, Bertollo N, Christou C, Schaffner D, Mobbs RJ. Biomechanical evaluation and surface characterization of a nano-modified surface on PEEK implants: a study in the rabbit tibia, Int J Nanomedicine. Johansson P, Jimbo R, Kjellin P, Currie F, Chrcanovic BR, and Wennerberg A. Polyetheretherketone as a biomaterial for spinal applications. Toth JM, Wang M, Estes BT, Scifert JL, Seim HB 3rd, Turner AS. PEEK biomaterials in trauma, orthopedic, and spinal implants. Learn more about NanoTitanium and read our whitepaper here. We are frequently audited by our customers, maintaining greater than 99.7% process yield with robust and complete systems for control of processes. We operate in a 27,000 square foot facility housing office, laboratory, manufacturing, and cleanroom space to service all customer and regulatory requirements. N2 Biomedical is ISO-13485 certified and FDA GMP-compliant. The ion bombardment also eliminates the columnar microstructure often observed in conventional, low temperature physical vapor deposition to create very dense, adherent film structures. Unlike conventional Physical Vapor Deposition (PVD) processes, such as thermal evaporation or sputtering,the concurrent ion bombardment in the IBAD process intermixes coating and substrate atoms and significantly improves adhesion while permitting control of film morphology, density, stress level, crystallinity, and chemical composition on a nano-scale. N2’s NanoTitanium coatings are applied using Ion Beam Assisted Deposition (IBAD) technique, which deposits a highly adherent thin film at low-temperature in a high vacuum environment. The excellent coating adhesion is achieved by combining electron-beam evaporation with simultaneous ion beam bombardment. Previously operating under the name Spire Biomedical, the company has been the innovator in ion beam technology for over 30 years and processes over 500,000 implants per year for Tier 1 orthopedic, cardiovascular and orthodontic companies around the world. N2 Biomedical provides highly engineered surface treatments and nanoengineered coating services to the medical device OEMs. ![]() More recently, these efforts have also included enhancing the anti-microbial properties of titanium coated implants by engineering surface features on a nano-scale to prevent bacterial adhesion and biofilm formation.9,10 Ion Beam Assisted Deposition (IBAD) process To address this limitation, researchers have increasingly focused on forming a coating of titanium on PEEK-based implants to improve surface functionality and bone attachment and integration, while at the same time maintaining the native benefits of PEEK implants, including imaging characteristics and mechanical properties.4-8 Coating deposition techniques such as thermal plasma spray (TPS) and physical vapor deposition (PVD) have been employed to form titanium layers with roughness or topographies in the macro-, micro-, and nano-scale, in order to create surfaces more favorable to bone apposition and osseointegration. Polyether ether ketone, more commonly referred to as PEEK, has increasingly been used in recent years as an implant material for orthopedic and spinal devices (such as spinal interbodies, dental implants, screws, and small joints) in part due to its inherent properties such as chemical inertness, radiolucency, and an elastic modulus that is closely matched to natural bone.1,2 Despite these advantages, a major limitation of untreated PEEK implants is their hydrophobic surface which leads to relatively poor bone tissue attachment as compared to titanium-based devices.3 Complications associated with poor osseointegration or anchoring of the bone tissue to PEEK interbody devices can lead to pseudo-arthrosis and failure of the fusion.1,2 Addressing limitations developing solutions ![]()
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